The film "Trouble With The Curve" saw Sandra Bullock walk away, but has a couple of actresses vying for the lead.
Amy Adams and Reese Witherspoon are both in the running for the lead opposite Clint Eastwood. The film is about a basketball scout (Eastwood) who, because of his failing eyesight, sets out on one last trip. The female lead would play Eastwood's daughter, who accompanies him.